Tomasz Wypych

Tomasz Wypych , PhD

Head of Laboratory

t.wypych@nencki.edu.pl

Dr. Tomasz Wypych is a distinguished researcher in biological sciences, currently leading a research group at the Nencki Institute of Experimental Biology, Polish Academy of Sciences in Warsaw since April 2021. He earned his Ph.D. with distinction (insigni cum laude) in 2016 from the Institute for Research in Biomedicine in Switzerland, and has recently successfully completed his habilitation, receiving the degree of Habilitated Doctor in biological sciences. His academic journey includes significant postdoctoral work at the University Hospital of Lausanne and Monash University, focusing on immunology and pathology. Dr. Wypych's scientific output includes 16 publications, with a cumulative Impact Factor of 224.5 and an H-index of 10 according to Web of Science5. His research primarily focuses on the intricate interplay between the host and microbiota, particularly its role in asthma development, as highlighted in his habilitation work "Identification of host-microbiota interactions preventing asthma development". He has notably explored the influence of B lymphocytes in allergic responses and the protective mechanisms of gut microbiota metabolites, such as p-cresol sulfate, against allergic airway inflammation. Furthermore, his work sheds light on how early-life antibiotic use impacts gut microbiota and asthma susceptibility, proposing indole-3-propionic acid (IPA) as a potential therapeutic modulator. Dr. Wypych has been awarded five prestigious grants, including the NHMRC Australia Ideas Grant and several Polish National Science Centre grants9. He is also recognized for his organizational contributions, serving as a key organizer for various scientific conferences and as a coordinator for the Nencki Institute's Institutional Seminar Series. His commitment to scientific dissemination is evident through his roles as a Review Editor for Frontiers in Immunology and Microorganisms, and his active participation in reviewing for top-tier journals. He was also honored with the Minister of Science and Higher Education Scholarship for Outstanding Young Scientists (2022-2025).

Selected publications:

  1. Davis, J., Wypych, TP. (2021), Cellular and functional heterogeneity of the airway epithelium, Mucosal Immunol.
    https://doi.org/10.1038/s41385-020-00370-7
  2. Wypych, TP., Pattaroni, C., Perdijk, O., Yap, C., Trompette, A., Anderson, D., Creek, D., Harris, NL and Marsland, BJ* (2021), Microbial metabolism of L-tyrosine protects against allergic airway inflammation. Nat Immunol 22, 279-286
    https://doi.org/10.1038/s41590-020-00856
  3. Wypych, TP., Wickramasinghe, LK., Marsland, BJ (2019), The influence of the microbiome on respiratory health. Nat Immunol 20, 1279-1290
    https://doi.org/10.1038/s41590-019-0451-9
  4. Wypych, TP., Marsland, BJ. (2018), Antibiotics as instigators of microbial dysbiosis: implications for asthma and allergy. Trends Immunol 39, 697-711
    https://doi.org/10.1016/j.it.2018.02.008
  5. Wypych, TP., Marsland, BJ., Ubags, NDJ. (2017), The Impact of Diet on Immunity and Respiratory Diseases. Ann Am Thorac Soc, 14(Supplement_5):S339-S347.
    https://doi.org/10.1513/lsATS.201703-255AW
  6. Wypych, TP., Marsland, BJ. (2017), Diet Hypotheses in Light of the Microbiota Revolution: New Perspectives, Nutrients 9(6), 537.
    https://doi.org/10.3390/nu9060537
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